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2022

  1. Dadhich, R., Kapoor, S*. (2022) Lipidomic and Membrane Mechanical Signatures in Triple-Negative Breast Cancer: Scope for Membrane-Based Theranostics. Mol Cell Biochem. https://doi.org/10.1007/s11010-022-04459-4.

  2. Adhyapak, P., Dong, W., Dasgupta, S., Dutta, A., Duna, M., Kapoor, S*. (2022) Lipid clustering in mycobacterial cell envelope layers governs spatially resolved solvation dynamics. Chem Asian J. Apr 13:e202200146. doi: 10.1002/asia.202200146. Epub ahead of print. PMID: 35419975.

  3. Menon, AP., Dong, W., Lee, TH., Aguilar, MI., Duan, M., Kapoor, S*. (2022) Mycobacterial Cell Envelope Membrane Layers offer Insights for Membrane-Centric Therapy in Infectious Diseases. ACS Bio. Med. Chem Au. doi.org/10.1021/acsbiomedchemau.2c00010

  4. Mishra, M., Kapoor, S* (2022). Multifaceted Roles of Mycobacterium Cell Envelope Glycolipids during Host Cell Membrane Interactions. Biology of Mycobacterial Lipids. Elsevier Inc. Just Accepted.

  5. Agarwala, P.K., Aneja, R., Kapoor, S*. (2022) Lipidomic Landscape in Cancer: Actionable Insights for Membrane-Based Therapy and Diagnoses. Med Res Rev.42:983–1018.

  6. Modak., B., Girkar, S., Narayan, R., Kapoor, S*., (2022) Mycobacterial membranes as actionable targets for lipid-centric therapy in Tuberculosis. J. Med. Chem. 65, 4, 3046–3065 

2021

  1. Garlapati, C., Joshi, S., Turaga, RC.,  Mishra, M.,  Reid,  MD., Kapoor, S., Artinian, L., Rehder, V., Aneja, R. (2021). Monoethanolamine-induced glucose deprivation promotes apoptosis through metabolic rewiring in prostate cancer. Theranostics. 11 (18), 9089.

  2. Srivatsav, A., Kapoor, S* (2021). The Emerging World of Membrane Vesicles: Functional Relevance, Theranostic Avenues and Tools for Investigating Membrane Function. Frontiers in Molecular Biosciences. doi.org/10.3389/fmolb.2021.640355.

  3. Ghosh, I., Singh, RK., Mishra, M., Kapoor, S., Jana, SS (2021). Switching between blebbing and lamellipodia depends on the degree of Nonmuscle Myosin II activity. Journal of Cell Science 13;134,jcs248732. 10.1242/jcs.248732

  4. Saha. P., Agarwala, PK., Dadhich, R., Adhyapak, P., Kapoor, S*., Madhavan, N* (2021). Ligand Induced Cu(II) Transport restricts Cancer and Mycobacterial Growth: Towards a Plug-and-Select Ion Channel Scaffold. Chembiochem. 22(8), 1424-1429. doi: 10.1002/cbic.202000731

2020

  1. Kumar, G., Narayan, R*., Kapoor, S* (2020). Chemical Tools for Illumination of Tuberculosis Biology, Virulence Mechanisms, and Diagnosis. J. Med. Chem. 2020, 63, 24, 15308–15332

  2. Zhao, L., Rupji, M., Kapoor, S., Yang, C., Aneja, R (2020). Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer. Scientific Reports, 10(1),19182. 

  3. Dadhich, R., and Kapoor, S* (2020) Various Facets of Pathogenic Lipids in Infectious Diseases: Exploring Virulent Lipid-Host Interactome and Their Druggability. Journal of Membrane Biology 253(5), 399-423.

  4. Mishra, M., Dadhich, R., Mogha, P., and Kapoor, S*. (2020) Mycobacterium Lipids Modulate Host Cell Membrane Mechanics, Lipid Diffusivity, and Cytoskeleton in a Virulence-Selective Manner. ACS Infectious Diseases, 6(9), 2386-2399. doi/10.1021/acsinfecdis.0c00128.

  5. Mishra, M., Kapoor, S*. Modulation of host cell membrane nanoenvironment by mycobacterial glycolipids: Involvement of PI(4,5)P2 signaling lipid? (2020) Faraday Discussions. doi.org/10.1039/D0FD00051E.

  6. Dadhich, R., Mishra, M., Ning, S., Jana, S., Sarpe, VA., Mahato, J., Duan, M*. Kulkarni, SS*, Kapoor, S*. (2020) A virulence-associated lipid with distinct conformational attributes: Impact on lateral organization of host plasma membrane and signaling. ACS Chem. Biol. 15, 3, 740-750.

  7. Adhyapak, P., Srivatsav, A., Mishra, M., Singh, A., Narayan, R., Kapoor, S*. (2020) Dynamical Organization of Compositionally Distinct Inner and Outer Membrane Lipids of Mycobacteria. Biophysical Journal, 118, 1279-1291.

2019

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  1. Mishra, M., Adhyapak, P., Dadhich, R., Kapoor, S*. (2019) Dynamic Remodeling of the Host Cell Membrane by Virulent Mycobacterial Sulfoglycolipid-1. Scientific Reports. 9:12844.

  2. Adhyapak, P. and Kapoor, S*. (2019). Membrane Dynamics in Health and Disease: Impact on Cellular Signalling. J Membrane Biol. https://doi.org/10.1007/s00232-019-00087-0.

  3. Cromm, PM., Adihou, H., Kapoor, S., et al. (2019). Lipidated stapled peptides targeting the acyl binding protein UNC119. ChemBioChem, 20, 2987-2990.

  4. Freise, A#., Kapoor, S#., Schneidewind, T., Waldmann, H et al. (2019). Chemical genetics reveals role of dCTP pyrophosphatase 1 in Wnt signalling. Angew Chem. Int. Ed. 58, 1-6. # Equal Contribution.

  5. Garlapati, C., Joshi, S., Sahoo, B., Kapoor, S*., Aneja, R.* (2019). The persisting puzzle of racial disparity in triple negative breast cancer: looking through a new lens. Frontiers In Bioscience, 11, 75-88.

  6. Dadhich, R., Singh, A., Menon, AP., Mishra, M., C D Athul., Kapoor, S*. (2019). Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis. Biochimica et Biophysica Acta (BBA) - Biomembranes,1861, 1213-1227.

  7. Kapoor, S., Schneidewind, T., et al. (2019). Cell Chemical Biology, 26, 1–12.

2018

  1. Aswin T. Srivatsav, Manjari Mishra, Shobhna Kapoor (2018) Small-Molecule Modulation of Lipid-Dependent Cellular Processes against Cancer: fats of the Gunpoint. BioMed Research International. ID 6437371. doi.org/10.1155/2018/6437371.

  2. Brand S., Roy S., Kapoor S., et. al. (2018) Combined Proteomic and In Silico Target Identification Reveal a New Role for 5-lipoxygenase in Developmental Signaling Pathways. Cell Chemical Biology  25, 1095-1106.

2017

  1. Kapoor, S., Sheremet, M., Schröder, P., Kumar, K., Ziegler, S., Waldmann, H. (2017). Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling. ChemBioChem. 18, 1797-1806.

Publications from before joining IIT Bombay

2016

  1. Kapoor, S., Ziegler, S., Waldmann, H. (2016). Novel Approaches to Map Small Molecule-Target Interactions. Bioorganic and Medicinal Chemistry. 24, 3232-3245.

  2. Sperlich, B., Kapoor, S., Waldmann, H., Winter, H., and Weise, K. (2016). Regulation of K-Ras4B membrane binding by calmodulin. Biophysical Journal, 111, 113-122.

  3. Kapoor, S., and Winter, R. (2016). Pressure Perturbation: A Prime Tool to Study Conformational Substates and Volume Fluctuations of Biomolecular Assemblies. In: Molecular Science of Fluctuations towards Biological Functions. Springer. pp 29-64.

2015

  1. Luong, T.Q., Kapoor, S., and Winter, R. (2015). Pressure—A Gateway to Fundamental Insights into Protein Solvation, Dynamics and Function. ChemPhysChem. 16, 3555-3571. Cover Picture

  2. Kapoor, S., Fansa, E.K., Möbitz, S., Ismail, S.A., Winter, R., Wittinghofer, A., and Weise, K. (2015). Effect of the N-terminal Helix and Nucleotide Loading on the Membrane and Effector binding of Arl2/3. Biophysical Journal. 109, 1619-1629.

2013

  1. Kapoor, S., Werkmueller, A., Goody, R.S., Waldmann, H., and Winter, R. (2013). Pressure modulation of Ras-Membrane interactions and intervesicle transfer.  J. Am. Chem. Soc. 135, 6149-6156.

  2. Prigozhin, M.B., Liu, Y., Wirth, A.J., Kapoor, S., Winter, R., Schulten, K., and Gruebele, M. (2013) Misplaced Helix Slows Down Ultrafast Pressure-Jump Protein Folding. Proc. Natl. Acad. Sci. U.S.A. 110, 8087-8092.

  3. Weise, K., Huster, D., Kapoor, S., Triola, G., Waldmann, H., and Winter, R. (2013) Gibbs energy determinants of lipoprotein insertion into lipid membranes: The case study of Ras proteins. Faraday Discussions, 549-561.

2014

  1. Kapoor, S., Berghaus, M., Suladze, S., Prumbaum, D., Grobelny, S., Degen, P., Raunser, S., and Winter, R. (2014). Prebiotic Cell Membranes Survive Extreme Environmental Pressure Conditions.  Angew. Chem. Int. Ed. 53, 8397-8401.

  2. Georget, E., Kapoor, S., Winter, R., Reineke, K., Song, Y., Callanan, M., Ananta, E., Heinz, V., and Mathys, A. In Situ Investigation of Geobacillus Stearothermophilus Spore Germination and Inactivation Mechanisms under Moderate High Pressure. Food Microbiol. 41, 8-18.

2012

  1. Kapoor, S., Weise, K., Erlkamp, M., Triola, G., Waldmann, H., and Winter, R. (2012). The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction. Eur. Biophys. J. 41, 801-813.

  2. Kapoor, S., Triola, G., Vetter, I.R., Erlkamp, M., Waldmann, H., and Winter, R. (2012). Revealing conformational substates of lipidated N-Ras protein by pressure modulation. Proc. Natl. Acad. Sci. U.S.A. 109, 460-465.

  3. Weise, K., Kapoor. S., Wekmüller, A., Möbitz, S., Zimmermann, G., Triola, G., Waldmann, H., and Winter, R. (2012) Dissociation of the K-Ras4B/PDEδ complex upon contact with lipid membranes: Membrane delivery instead of extraction. J. Am. Chem. Soc. 134, 11503-11510.

  4. Seeliger, J., Evers, F., Jeworrek, C., Kapoor. S., Weise, K., Andreetto, E., Tolan, M., Kapurniotu, A., and Winter, R. (2012) Cross-amyloid interaction of Aβ and IAPP at lipid membranes. Angew. Chem. Int. Ed. 51, 679-683.

  5. Barackov, I., Kapoor, S., Mause, A., Winter, R., Schembecker, G., and Burghoff, B. (2012) Investigation of structural changes of β-casein and lysozyme at the gas-liquid interface during foam fractionation. J. Biotech. 161, 138-146.

  6. Henke, S., Schneemann, A., Kapoor, S., Winter, R., and Fischer. RA. (2012). Zinc-1,4-benzenedicarboxylate-bipyridine frameworks - Linker functionalization impacts network topology during solvothermal synthesis. J. Mat. Chem. 22, 909-918.

2011

  1. Weise, K., Kapoor, S., Denter, C., Nikolaus, J., Opitz, N., Koch, S., Triola, G., Herrmann, A., Waldmann, H., and Winter, R. (2011) Membrane-Mediated Induction and Sorting of K-Ras Microdomain Signaling Platforms. J. Am. Chem. Soc. 133, 880-887. Cover Article

  2. Kapoor, S., Werkmuller, A., Denter, C., Zhai, Y., Markgraf, J., Weise, K., Opitz, N., and Winter, R. (2011). Temperature-pressure phase diagram of a heterogeneous anionic model biomembrane system: Results from a combined calorimetry, spectroscopy and microscopy study. Biochim. Biophys.Acta, Biomembr. 1808, 1187-1195. 

2010

  1. Kapoor, S., Girish, TS., Mandal, SS., Gopal, B., and Bhattacharyya, AJ. (2010). Inhibition of a protein tyrosine phosphatase using mesoporous oxides. J. Phys. Chem. B. 114, 3117–3121.

2009

  1. Kapoor, S., Hegde, R., and Bhattcharyya, AJ. (2009). Influence of Surface Chemistry of Mesoporous Alumina with Wide Pore Size Distribution on Controlled Release. J. Controlled Release. 140, 34–39.

  2. Kapoor, S., Mondal, SS., and Bhattacharyya, AJ. (2009). Structure and Function of Hemoglobin Confined Inside Silica Nanotubes. J. Phys. Chem. B. 113, 14189–14195. Cover article.

  3. Kapoor, S., and Bhattacharyya, AJ. (2009). Ultrasound–Triggered Controlled Drug Delivery and Biosensing Using Silica Nanotubes. J. Phys. Chem. C. 113, 7155–7163. 

  4. Das, SK., Kapoor, S., Yamada, H., and Bhattacharyya, AJ. (2009). Effects of Surface acidity and pore size of Mesoporous alumina on degree of loading and controlled release of Ibuprofen. Microporous and Mesoporous Materials 118, 267–272.

2008

  1. Argen, D., Stehr, M., Berthold, CL., Kapoor, S., Oehlmann, W., Singh, M., and Schneider, G. Three-dimensional Structure of Apo and Holo-I-Alanine Dehydrogenase from Myobacterium Tuberculosis Reveal Conformational Changes upon Coenyzme Binding. J. Mol. Biol. 377, 1161-1173.

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